Can I Run Devstral-2 22B on NVIDIA GeForce RTX 5080?

Written by Jakub Rusinowski · Last updated August 15, 2026

Yes. Devstral-2 22B needs 13.3 GB at Q4_K_M and the NVIDIA GeForce RTX 5080 has 16 GB, leaving about 2.7 GB of headroom, at roughly 51 tok/s (estimated) with room for up to 4K of context.

The numbers

ModelDevstral-2 22B
Parameters22B
QuantizationQ4_K_M
VRAM needed13.3 GB
NVIDIA GeForce RTX 5080 VRAM16 GB
VerdictRuns
Max context4K
Estimated speed~51 tok/s

What to do next

Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.

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Running Devstral-2 22B on this card:

NVIDIA GeForce RTX 5080 16GB
16 GB VRAM · 360 W board power
2026 prices are volatile — check the current listing.
Check price on Amazon

Buy vs. rent Devstral-2 22B
Buy the GPU
~$999
NVIDIA GeForce RTX 5080 · MSRP
Rent by the hour
from $0.34/hr
RTX 4090 (24 GB) class

At 2 hrs/day, buying (~$999) beats renting at $0.34/hr after about 4.1 years.

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RunPod $0.34/hr
Rent on RunPod →
Vast.ai $0.35/hr · typical low · varies
Rent on Vast.ai →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other Devstral sizes on the NVIDIA GeForce RTX 5080

Devstral-2 22B on nearby hardware

All Devstral sizes on the NVIDIA GeForce RTX 5080 | VRAM calculator for Devstral-2 22B | NVIDIA GeForce RTX 5080 GPU page | Check your hardware