Can I Run GPT-OSS on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM)?

Written by Jakub Rusinowski · Last updated August 15, 2026

Yes, but it is tight

Yes, but it is tight — GPT-OSS 20B at Q5_K_M needs about 15.4 GB of the 16 GB usable on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM), leaving only ~0.6 GB before the runtime starts swapping. Expect ~45 tok/s (estimated), with room for about 16,384 tokens of context.

Confidence: medium · Recommended quantization: Q5_K_M · Estimated speed: ~45 tok/s

RTX 5080 Desktop (16 GB VRAM, 32 GB RAM) — what it gives a model

Usable memory for models16 GB
Memory bandwidth960 GB/s
Form factorDesktop
Operating systemWindows or Linux
Memory upgradeableYes

GPT-OSS on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM): memory by quantization

QuantMemory neededFits 16 GB?Max contextEst. speedDownload
F1641.2 GB✗ No40 GB
Q8_022.5 GB✗ No21.3 GB
Q6_K17.6 GB✗ No16.4 GB
Q5_K_M15.4 GB✓ Yes16K~45 tok/s14.2 GB
Q4_K_M13.3 GB✓ Yes32K~51.8 tok/s12.1 GB
Q3_K_M9.7 GB✓ Yes128K~69.6 tok/s8.5 GB
Q2_K7.8 GB✓ Yes128K~85.8 tok/s6.6 GB

Which GPT-OSS sizes fit

VariantNeeds at Q4_K_MFits?Est. speed
GPT-oss 120B73.9 GB✗ Too large
GPT-OSS 20B13.3 GB✓ Fits~51.8 tok/s

What to watch out for

RTX 5080 desktop limitations

Recommended setup

Ollama or llama.cpp (CUDA/ROCm) — vLLM if you need concurrent serving

How these numbers are calculated

FAQ

Can I run GPT-OSS on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM)?

Yes, but it is tight — GPT-OSS 20B at Q5_K_M needs about 15.4 GB of the 16 GB usable on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM), leaving only ~0.6 GB before the runtime starts swapping. Expect ~45 tok/s (estimated), with room for about 16,384 tokens of context.

Which quantization of GPT-OSS should I use on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM)?

Q5_K_M — it needs about 15.4 GB of the 16 GB available, downloads as roughly 14.2 GB, and runs at an estimated 45 tokens/sec with up to 16K of context.

What limits GPT-OSS on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM)?

Nothing binding — the model fits with headroom and generates at a usable speed on this hardware.

Which runtime should I use?

Ollama or llama.cpp (CUDA/ROCm) — vLLM if you need concurrent serving

Other Computers

Other Models on RTX 5080 Desktop (16 GB VRAM, 32 GB RAM)

GPT-OSS on GPUs

What This Model Is Good At

Model & Tools

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