Written by Jakub Rusinowski · Last updated August 15, 2026
Yes. Mistral NeMo 12B needs 7.2 GB at Q4_K_M and the NVIDIA GeForce RTX 5090 has 32 GB, leaving about 24.8 GB of headroom, at roughly 134 tok/s (estimated) with room for up to 128K of context.
| Model | Mistral NeMo 12B |
| Parameters | 12B |
| Quantization | Q4_K_M |
| VRAM needed | 7.2 GB |
| NVIDIA GeForce RTX 5090 VRAM | 32 GB |
| Verdict | Runs |
| Max context | 128K |
| Estimated speed | ~134 tok/s |
Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.
Running Mistral NeMo 12B on this card:
At 2 hrs/day, buying (~$1,999) beats renting at $0.34/hr after about 8.2 years.
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Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.
All Mistral Family sizes on the NVIDIA GeForce RTX 5090 | VRAM calculator for Mistral NeMo 12B | NVIDIA GeForce RTX 5090 GPU page | Check your hardware