Can I Run Gemma 3n on Framework Desktop (Ryzen AI Max+ 395, 128 GB)?

Written by Jakub Rusinowski · Last updated April 1, 2025

Yes — comfortably

Yes, comfortably — Gemma 3n E4B at Q8_0 needs about 10.3 GB of the 128 GB usable on Framework Desktop (Ryzen AI Max+ 395, 128 GB), leaving ~117.7 GB spare and running at ~37.5 tok/s (estimated), with room for about 32,768 tokens of context.

Confidence: medium · Recommended quantization: Q8_0 · Estimated speed: ~37.5 tok/s

Framework Desktop (Ryzen AI Max+ 395, 128 GB) — what it gives a model

Usable memory for models128 GB
Memory bandwidth256 GB/s
Form factorMini PC
Operating systemWindows or Linux
Memory upgradeableNo — soldered

Gemma 3n on Framework Desktop (Ryzen AI Max+ 395, 128 GB): memory by quantization

QuantMemory neededFits 128 GB?Max contextEst. speedDownload
F1617.6 GB✓ Yes32K~21.9 tok/s15.7 GB
Q8_010.3 GB✓ Yes32K~37.5 tok/s8.3 GB
Q6_K8.4 GB✓ Yes32K~45.9 tok/s6.4 GB
Q5_K_M7.5 GB✓ Yes32K~51.2 tok/s5.6 GB
Q4_K_M6.7 GB✓ Yes32K~57.4 tok/s4.7 GB
Q3_K_M5.3 GB✓ Yes32K~72.3 tok/s3.3 GB
Q2_K4.5 GB✓ Yes32K~84.3 tok/s2.6 GB

Which Gemma 3n sizes fit

VariantNeeds at Q4_K_MFits?Est. speed
Gemma 3n E4B6.7 GB✓ Fits~57.4 tok/s
Gemma 3n E2B5.1 GB✓ Fits~92 tok/s

What to watch out for

Framework Desktop 128 GB limitations

Recommended setup

Ollama or llama.cpp (CUDA/ROCm) — vLLM if you need concurrent serving

How these numbers are calculated

FAQ

Can I run Gemma 3n on Framework Desktop (Ryzen AI Max+ 395, 128 GB)?

Yes, comfortably — Gemma 3n E4B at Q8_0 needs about 10.3 GB of the 128 GB usable on Framework Desktop (Ryzen AI Max+ 395, 128 GB), leaving ~117.7 GB spare and running at ~37.5 tok/s (estimated), with room for about 32,768 tokens of context.

Which quantization of Gemma 3n should I use on Framework Desktop (Ryzen AI Max+ 395, 128 GB)?

Q8_0 — it needs about 10.3 GB of the 128 GB available, downloads as roughly 8.3 GB, and runs at an estimated 37.5 tokens/sec with up to 32K of context.

What limits Gemma 3n on Framework Desktop (Ryzen AI Max+ 395, 128 GB)?

Nothing binding — the model fits with headroom and generates at a usable speed on this hardware.

Which runtime should I use?

Ollama or llama.cpp (CUDA/ROCm) — vLLM if you need concurrent serving

Other Computers

Other Models on Framework Desktop (Ryzen AI Max+ 395, 128 GB)

Gemma 3n on GPUs

What This Model Is Good At

Model & Tools

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