Can I Run GPT-OSS 20B on AMD Ryzen AI Max+ 395?

Written by Jakub Rusinowski · Last updated August 15, 2026

Yes. GPT-OSS 20B needs 10.6 GB at MXFP4 and the AMD Ryzen AI Max+ 395 has 96 GB, leaving about 85.4 GB of headroom, at roughly 15 tok/s (estimated) with room for up to 128K of context.

The numbers

ModelGPT-OSS 20B
Parameters20B
QuantizationMXFP4
VRAM needed10.6 GB
AMD Ryzen AI Max+ 395 VRAM96 GB
VerdictRuns
Max context128K
Estimated speed~15 tok/s

What to do next

Nothing to change — run it at MXFP4. If you want more capability, check whether the next size up also fits.

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Running GPT-OSS 20B on this card:

Ryzen AI Max+ 395 Laptop (Strix Halo, up to 128GB)
96 GB VRAM · 120 W board power
2026 prices are volatile — check the current listing.
Check price on Amazon

Buy vs. rent GPT-OSS 20B
Buy the GPU
~$1,999
AMD Ryzen AI Max+ 395 · MSRP
Rent by the hour
from $0.34/hr
RTX 4090 (24 GB) class

At 2 hrs/day, buying (~$1,999) beats renting at $0.34/hr after about 8.2 years.

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RunPod $0.34/hr
Rent on RunPod →
Vast.ai $0.35/hr · typical low · varies
Rent on Vast.ai →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other GPT-OSS sizes on the AMD Ryzen AI Max+ 395

GPT-OSS 20B on nearby hardware

All GPT-OSS sizes on the AMD Ryzen AI Max+ 395 | VRAM calculator for GPT-OSS 20B | AMD Ryzen AI Max+ 395 GPU page | Check your hardware