Can I Run Nemotron 70B on AMD Ryzen AI Max+ 395?
Written by Jakub Rusinowski · Last updated July 12, 2026
Yes, comfortably — Nemotron 70B Instruct at Q4_K_M needs 46.1 GB at 8K context (42.6 GB weights + 3.5 GB KV cache/overhead), leaving ~81.9 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 64K context.
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AMD Ryzen AI Max+ 395 Specs
| VRAM | 128 GB |
| Memory Bandwidth | 256 GB/s |
Nemotron 70B Instruct on the AMD Ryzen AI Max+ 395: VRAM by quantization
| Quant | VRAM needed | Fits 128 GB? | Max context | Whole PC |
|---|---|---|---|---|
| F16 | 144.7 GB | ✗ No | — | — |
| Q8_0 | 78.5 GB | ✓ Yes | 64K | — |
| Q6_K | 61.4 GB | ✓ Yes | 64K | — |
| Q5_K_M | 53.5 GB | ✓ Yes | 64K | — |
| Q4_K_M | 46.1 GB | ✓ Yes | 64K | — |
| Q3_K_M | 33.6 GB | ✓ Yes | 64K | — |
| Q2_K | 26.7 GB | ✓ Yes | 64K | — |
Assumes an 8K-token context with an f16 KV cache. A longer window needs more; a quantized KV cache needs less. “Max context” is the largest window that still fits in 128 GB. Figures are estimates from parameter count, quantization and memory bandwidth — the analyzer lets you tune KV-cache quant and context.
Context costs VRAM too. At Q4_K_M on the AMD Ryzen AI Max+ 395: 8K 46.1 GB · 32K 54.2 GB · 125K 85.4 GB. Every window this model publishes still fits 128 GB.
No compatible GPU? Nemotron 70B Instruct on 256 GB of system RAM, CPU only: runs, but too slowly to be worth it.
Nemotron 70B Sizes That Fit the AMD Ryzen AI Max+ 395 (at 8K context)
| Nemotron 70B Instruct | Q4_K_M · 46.1 GB at 8K context · ~4 tok/s (est.) |
Nemotron 70B needs ~46 GB but this GPU has 128 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:
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FAQ
Will Nemotron 70B run on the AMD Ryzen AI Max+ 395?
Yes, comfortably — Nemotron 70B Instruct at Q4_K_M needs 46.1 GB at 8K context (42.6 GB weights + 3.5 GB KV cache/overhead), leaving ~81.9 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 64K context.
Which Nemotron 70B variant fits best on the AMD Ryzen AI Max+ 395?
Nemotron 70B Instruct at Q4_K_M quantization needs 46.1 GB at 8K context (42.6 GB weights + 3.5 GB KV cache/overhead), estimated ~4 tokens/sec, up to 64K context.
Nemotron 70B on Other GPUs
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