Can I Run Qwen 2.5 Family on AMD Ryzen AI Max+ 395?
Written by Jakub Rusinowski · Last updated July 12, 2026
Yes, comfortably — Qwen 2.5 72B Instruct at Q4_K_M needs 47 GB at 8K context (43.5 GB weights + 3.5 GB KV cache/overhead), leaving ~81 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 128K context.
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AMD Ryzen AI Max+ 395 Specs
| VRAM | 128 GB |
| Memory Bandwidth | 256 GB/s |
Qwen 2.5 72B Instruct on the AMD Ryzen AI Max+ 395: VRAM by quantization
| Quant | VRAM needed | Fits 128 GB? | Max context | Whole PC |
|---|---|---|---|---|
| F16 | 147.5 GB | ✗ No | — | — |
| Q8_0 | 80 GB | ✓ Yes | 128K | — |
| Q6_K | 62.5 GB | ✓ Yes | 128K | — |
| Q5_K_M | 54.5 GB | ✓ Yes | 128K | — |
| Q4_K_M | 47 GB | ✓ Yes | 128K | — |
| Q3_K_M | 34.2 GB | ✓ Yes | 128K | — |
| Q2_K | 27.2 GB | ✓ Yes | 128K | — |
Assumes an 8K-token context with an f16 KV cache. A longer window needs more; a quantized KV cache needs less. “Max context” is the largest window that still fits in 128 GB. Figures are estimates from parameter count, quantization and memory bandwidth — the analyzer lets you tune KV-cache quant and context.
Context costs VRAM too. At Q4_K_M on the AMD Ryzen AI Max+ 395: 8K 47 GB · 32K 55 GB · 128K 87.2 GB. Every window this model publishes still fits 128 GB.
No compatible GPU? Qwen 2.5 Family on 8 GB of system RAM, CPU only: runs, but it is tight.
Qwen 2.5 Family Sizes That Fit the AMD Ryzen AI Max+ 395 (at 8K context)
| Qwen 2.5 72B Instruct | Q4_K_M · 47 GB at 8K context · ~4 tok/s (est.) |
| Qwen 2.5 Coder 32B | Q4_K_M · 22.3 GB at 8K context · ~8 tok/s (est.) |
| Qwen 2.5 14B Instruct | Q4_K_M · 10.9 GB at 8K context · ~17 tok/s (est.) |
| Qwen 2.5 7B Instruct | Q4_K_M · 5.9 GB at 8K context · ~31 tok/s (est.) |
Qwen 2.5 Family needs ~47 GB but this GPU has 128 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:
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Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.
FAQ
Qwen 2.5 Family on the AMD Ryzen AI Max+ 395 — does it fit?
Yes, comfortably — Qwen 2.5 72B Instruct at Q4_K_M needs 47 GB at 8K context (43.5 GB weights + 3.5 GB KV cache/overhead), leaving ~81 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 128K context.
Which Qwen 2.5 Family variant fits best on the AMD Ryzen AI Max+ 395?
Qwen 2.5 72B Instruct at Q4_K_M quantization needs 47 GB at 8K context (43.5 GB weights + 3.5 GB KV cache/overhead), estimated ~4 tokens/sec, up to 128K context.
Every Qwen 2.5 Family size on the AMD Ryzen AI Max+ 395
| Size | VRAM at 8K | Verdict | Speed |
|---|---|---|---|
| Qwen 2.5 72B Instruct | 47 GB | Runs | ~4 tok/s |
| Qwen 2.5 Coder 32B | 22.3 GB | Runs | ~8 tok/s |
| Qwen 2.5 14B Instruct | 10.9 GB | Runs | ~17 tok/s |
| Qwen 2.5 7B Instruct | 5.9 GB | Runs | ~31 tok/s |
Qwen 2.5 Family on Other GPUs
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