Can I Run Nemotron Cascade 2 on AMD Ryzen AI Max+ 395?
Written by Jakub Rusinowski · Last updated September 11, 2026
Yes, comfortably — Nemotron Cascade 2 70B at Q4_K_M needs 45.4 GB at 8K context (42.3 GB weights + 3.1 GB KV cache/overhead), leaving ~82.6 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 64K context.
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AMD Ryzen AI Max+ 395 Specs
| VRAM | 128 GB |
| Memory Bandwidth | 256 GB/s |
Nemotron Cascade 2 70B on the AMD Ryzen AI Max+ 395: VRAM by quantization
| Quant | VRAM needed | Fits 128 GB? | Max context | Whole PC |
|---|---|---|---|---|
| F16 | 143.2 GB | ✗ No | — | — |
| Q8_0 | 77.6 GB | ✓ Yes | 64K | — |
| Q6_K | 60.6 GB | ✓ Yes | 64K | — |
| Q5_K_M | 52.8 GB | ✓ Yes | 64K | — |
| Q4_K_M | 45.4 GB | ✓ Yes | 64K | — |
| Q3_K_M | 33 GB | ✓ Yes | 64K | — |
| Q2_K | 26.2 GB | ✓ Yes | 64K | — |
Assumes an 8K-token context with an f16 KV cache, on an estimated architecture — this model publishes no config we can read. A longer window needs more; a quantized KV cache needs less. “Max context” is the largest window that still fits in 128 GB. Figures are estimates from parameter count, quantization and memory bandwidth — the analyzer lets you tune KV-cache quant and context.
Context costs VRAM too. At Q4_K_M on the AMD Ryzen AI Max+ 395: 8K 45.4 GB · 32K 52.6 GB · 125K 80.3 GB. Every window this model publishes still fits 128 GB.
No compatible GPU? Nemotron Cascade 2 on 24 GB of system RAM, CPU only: runs.
Nemotron Cascade 2 Sizes That Fit the AMD Ryzen AI Max+ 395 (at 8K context)
| Nemotron Cascade 2 70B | Q4_K_M · 45.4 GB at 8K context · ~4 tok/s (est.) |
| Nemotron-Cascade 2 30B-A3B | Q4_K_M · 21.7 GB at 8K context · ~46 tok/s (est.) |
Nemotron Cascade 2 needs ~45 GB but this GPU has 128 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:
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FAQ
Nemotron Cascade 2 on the AMD Ryzen AI Max+ 395 — does it fit?
Yes, comfortably — Nemotron Cascade 2 70B at Q4_K_M needs 45.4 GB at 8K context (42.3 GB weights + 3.1 GB KV cache/overhead), leaving ~82.6 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 64K context.
Which Nemotron Cascade 2 variant fits best on the AMD Ryzen AI Max+ 395?
Nemotron Cascade 2 70B at Q4_K_M quantization needs 45.4 GB at 8K context (42.3 GB weights + 3.1 GB KV cache/overhead), estimated ~4 tokens/sec, up to 64K context.
Nemotron Cascade 2 on Other GPUs
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