Can I Run Qwen 2.5 72B Instruct on AMD Ryzen AI Max+ 395?
Written by Jakub Rusinowski · Last updated July 12, 2026
Yes. Qwen 2.5 72B Instruct needs 47 GB at 8K context (43.5 GB weights + 3.5 GB KV cache/overhead) at Q4_K_M and the AMD Ryzen AI Max+ 395 has 128 GB, leaving about 81 GB of headroom, at roughly 4 tok/s (estimated) with room for up to 128K of context.
See what else this hardware can run →
The numbers
| Model | Qwen 2.5 72B Instruct |
| Parameters | 72B |
| Quantization | Q4_K_M |
| VRAM needed (8K context) | 47 GB |
| AMD Ryzen AI Max+ 395 VRAM | 128 GB |
| Verdict | Runs |
| Max context | 128K |
| Estimated speed | ~4 tok/s |
Qwen 2.5 72B Instruct on the AMD Ryzen AI Max+ 395: VRAM by quantization
| Quant | VRAM needed | Fits 128 GB? | Max context | Whole PC |
|---|---|---|---|---|
| F16 | 147.5 GB | ✗ No | — | — |
| Q8_0 | 80 GB | ✓ Yes | 128K | — |
| Q6_K | 62.5 GB | ✓ Yes | 128K | — |
| Q5_K_M | 54.5 GB | ✓ Yes | 128K | — |
| Q4_K_M | 47 GB | ✓ Yes | 128K | — |
| Q3_K_M | 34.2 GB | ✓ Yes | 128K | — |
| Q2_K | 27.2 GB | ✓ Yes | 128K | — |
Assumes an 8K-token context with an f16 KV cache. A longer window needs more; a quantized KV cache needs less. “Max context” is the largest window that still fits in 128 GB. Figures are estimates from parameter count, quantization and memory bandwidth — the analyzer lets you tune KV-cache quant and context.
Context costs VRAM too. At Q4_K_M on the AMD Ryzen AI Max+ 395: 8K 47 GB · 32K 55 GB · 128K 87.2 GB. Every window this model publishes still fits 128 GB.
What to do next
Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.
No compatible GPU? Qwen 2.5 Family on 8 GB of system RAM, CPU only: runs, but it is tight.
Running Qwen 2.5 72B Instruct on this card:
Qwen 2.5 72B Instruct needs ~47 GB but this GPU has 128 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:
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Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.
Other Qwen 2.5 Family sizes on the AMD Ryzen AI Max+ 395
- Qwen 2.5 Coder 32B — runs (22.3 GB)
- Qwen 2.5 14B Instruct — runs (10.9 GB)
- Qwen 2.5 7B Instruct — runs (5.9 GB)
Qwen 2.5 72B Instruct on nearby hardware
- NVIDIA RTX PRO 6000 Blackwell (96 GB) — runs
All Qwen 2.5 Family sizes on the AMD Ryzen AI Max+ 395 | Qwen 2.5 72B Instruct model page | AMD Ryzen AI Max+ 395 GPU page | VRAM calculator | Check your hardware