Written by Jakub Rusinowski · Last updated August 15, 2026
Not at Q4_K_M — that needs 43.5 GB and the NVIDIA GeForce RTX 5090 has 32 GB. Drop to Q2_K and it fits in 27.2 GB, with up to 16K of context.
| Model | Qwen 2.5 72B Instruct |
| Parameters | 72B |
| Quantization | Q4_K_M |
| VRAM needed | 43.5 GB |
| NVIDIA GeForce RTX 5090 VRAM | 32 GB |
| Verdict | Runs at a lower quant |
| Fits at | Q2_K (27.2 GB) |
| Max context | 16K |
Quantize to Q2_K. That is the cheapest fix — it costs some quality but no money.
Running Qwen 2.5 72B Instruct on this card:
Qwen 2.5 72B Instruct needs ~43 GB but this GPU has 32 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:
Affiliate links — we may earn a commission if you sign up, at no extra cost to you.
Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.
All Qwen 2.5 Family sizes on the NVIDIA GeForce RTX 5090 | VRAM calculator for Qwen 2.5 72B Instruct | NVIDIA GeForce RTX 5090 GPU page | Check your hardware