Can I Run Qwen 2.5 72B Instruct on NVIDIA RTX 6000 Ada Generation?

Written by Jakub Rusinowski · Last updated August 15, 2026

Yes. Qwen 2.5 72B Instruct needs 43.5 GB at Q4_K_M and the NVIDIA RTX 6000 Ada Generation has 48 GB, leaving about 4.5 GB of headroom, at roughly 19 tok/s (estimated) with room for up to 8K of context.

The numbers

ModelQwen 2.5 72B Instruct
Parameters72B
QuantizationQ4_K_M
VRAM needed43.5 GB
NVIDIA RTX 6000 Ada Generation VRAM48 GB
VerdictRuns
Max context8K
Estimated speed~19 tok/s

What to do next

Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.

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Running Qwen 2.5 72B Instruct on this card:

NVIDIA RTX 6000 Ada Generation 48GB
48 GB VRAM · 300 W board power
2026 prices are volatile — check the current listing.
Check price on Amazon

Buy vs. rent Qwen 2.5 72B Instruct
Buy the GPU
~$6,799
NVIDIA RTX 6000 Ada Generation · MSRP
Rent by the hour
from $0.77/hr
A100 (80 GB) class

At 2 hrs/day, buying (~$6,799) beats renting at $0.77/hr after about 12.3 years.

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Vast.ai $0.77/hr · typical low · varies
Rent on Vast.ai →
RunPod $1.39/hr
Rent on RunPod →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other Qwen 2.5 Family sizes on the NVIDIA RTX 6000 Ada Generation

Qwen 2.5 72B Instruct on nearby hardware

All Qwen 2.5 Family sizes on the NVIDIA RTX 6000 Ada Generation | VRAM calculator for Qwen 2.5 72B Instruct | NVIDIA RTX 6000 Ada Generation GPU page | Check your hardware