Can I Run Qwen 2.5 VL on AMD Ryzen AI Max+ 395?
Written by Jakub Rusinowski · Last updated July 12, 2026
Yes, comfortably — Qwen 2.5 VL 72B Instruct at Q4_K_M needs 47.8 GB at 8K context (44.3 GB weights + 3.5 GB KV cache/overhead), leaving ~80.2 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 64K context.
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AMD Ryzen AI Max+ 395 Specs
| VRAM | 128 GB |
| Memory Bandwidth | 256 GB/s |
Qwen 2.5 VL 72B Instruct on the AMD Ryzen AI Max+ 395: VRAM by quantization
| Quant | VRAM needed | Fits 128 GB? | Max context | Whole PC |
|---|---|---|---|---|
| F16 | 150.3 GB | ✗ No | — | — |
| Q8_0 | 81.5 GB | ✓ Yes | 64K | — |
| Q6_K | 63.7 GB | ✓ Yes | 64K | — |
| Q5_K_M | 55.5 GB | ✓ Yes | 64K | — |
| Q4_K_M | 47.8 GB | ✓ Yes | 64K | — |
| Q3_K_M | 34.8 GB | ✓ Yes | 64K | — |
| Q2_K | 27.6 GB | ✓ Yes | 64K | — |
Assumes an 8K-token context with an f16 KV cache. A longer window needs more; a quantized KV cache needs less. “Max context” is the largest window that still fits in 128 GB. Figures are estimates from parameter count, quantization and memory bandwidth — the analyzer lets you tune KV-cache quant and context.
Context costs VRAM too. At Q4_K_M on the AMD Ryzen AI Max+ 395: 8K 47.8 GB · 32K 55.9 GB · 125K 87.1 GB. Every window this model publishes still fits 128 GB.
No compatible GPU? Qwen 2.5 VL on 8 GB of system RAM, CPU only: runs, but it is tight.
Qwen 2.5 VL Sizes That Fit the AMD Ryzen AI Max+ 395 (at 8K context)
| Qwen 2.5 VL 72B Instruct | Q4_K_M · 47.8 GB at 8K context · ~4 tok/s (est.) |
| Qwen 2.5 VL 7B Instruct | Q4_K_M · 6.3 GB at 8K context · ~29 tok/s (est.) |
Qwen 2.5 VL needs ~48 GB but this GPU has 128 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:
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Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.
FAQ
Is the AMD Ryzen AI Max+ 395 enough to run Qwen 2.5 VL locally?
Yes, comfortably — Qwen 2.5 VL 72B Instruct at Q4_K_M needs 47.8 GB at 8K context (44.3 GB weights + 3.5 GB KV cache/overhead), leaving ~80.2 GB of the AMD Ryzen AI Max+ 395's 128 GB, at ~4 tok/s (est.), with room for up to 64K context.
What's the best Qwen 2.5 VL size for the AMD Ryzen AI Max+ 395?
Qwen 2.5 VL 72B Instruct at Q4_K_M quantization needs 47.8 GB at 8K context (44.3 GB weights + 3.5 GB KV cache/overhead), estimated ~4 tokens/sec, up to 64K context.
Every Qwen 2.5 VL size on the AMD Ryzen AI Max+ 395
| Size | VRAM at 8K | Verdict | Speed |
|---|---|---|---|
| Qwen 2.5 VL 72B Instruct | 47.8 GB | Runs | ~4 tok/s |
| Qwen 2.5 VL 7B Instruct | 6.3 GB | Runs | ~29 tok/s |
Qwen 2.5 VL on Other GPUs
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