Can I Run Qwen 2.5 VL on AMD Ryzen AI Max+ 395?

Superseded model. Qwen 2.5 VL has been superseded by Qwen 3. This page is kept for reference; the newer family is a better starting point. View Qwen 3 →

Written by Jakub Rusinowski · Last updated July 12, 2026

Yes, comfortably — you'll have ~51.7 GB of headroom running Qwen 2.5 VL 72B Instruct at Q4_K_M (44.315250000000006 GB, ~4 tok/s (est.)) with room for up to 64K context.

Buy This HardwareGMKtec EVO-X2 (Ryzen AI Max+ 395, 128GB) — 96 GB VRAM · 120 W board powerDeploy in the Cloud NowNVIDIA A40 on RunPod — from $0.44/hr · rate checked 2026-08

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GMKtec EVO-X2 (Ryzen AI Max+ 395, 128GB)
96 GB VRAM · 120 W board power
2026 prices are volatile — check the current listing.
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AMD Ryzen AI Max+ 395 Specs

VRAM96 GB
Memory Bandwidth256 GB/s

Qwen 2.5 VL 72B Instruct on the AMD Ryzen AI Max+ 395: VRAM by quantization

QuantVRAM neededFits 96 GB?Max context
F16148.9 GB✗ No
Q8_080.1 GB✓ Yes32K
Q6_K62.3 GB✓ Yes64K
Q5_K_M54.2 GB✓ Yes64K
Q4_K_M46.5 GB✓ Yes64K
Q3_K_M33.4 GB✓ Yes64K
Q2_K26.3 GB✓ Yes64K

VRAM needed assumes a 4K-token context with an f16 KV cache; “Max context” is the largest window that still fits in 96 GB. Figures are estimates from parameter count, quantization and memory bandwidth — the analyzer lets you tune KV-cache quant and context.

Qwen 2.5 VL Sizes That Fit the AMD Ryzen AI Max+ 395

Qwen 2.5 VL 72B InstructQ4_K_M · 44.315250000000006 GB · ~4 tok/s (est.)
Qwen 2.5 VL 7B InstructQ4_K_M · 5.005087499999999 GB · ~29 tok/s (est.)
Buy vs. rent Qwen 2.5 VL
Buy the GPU
~$1,999
AMD Ryzen AI Max+ 395 · MSRP
Rent by the hour
from $0.77/hr
A100 (80 GB) class

At 2 hrs/day, buying (~$1,999) beats renting at $0.77/hr after about 3.6 years.

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Vast.ai $0.77/hr · typical low · varies
Rent on Vast.ai →
RunPod $1.39/hr
Rent on RunPod →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

FAQ

Is the AMD Ryzen AI Max+ 395 enough to run Qwen 2.5 VL locally?

Yes, comfortably — you'll have ~51.7 GB of headroom running Qwen 2.5 VL 72B Instruct at Q4_K_M (44.315250000000006 GB, ~4 tok/s (est.)) with room for up to 64K context.

What's the best Qwen 2.5 VL size for the AMD Ryzen AI Max+ 395?

Qwen 2.5 VL 72B Instruct at Q4_K_M quantization (44.315250000000006 GB), estimated ~4 tokens/sec, up to 64K context.

Qwen 2.5 VL on Other GPUs

Popular Models on the AMD Ryzen AI Max+ 395

VRAM Tier

Troubleshooting

Buying Guide

← Can I Run It? | Qwen 2.5 VL Model Page | AMD Ryzen AI Max+ 395 GPU Page | Check Your Hardware