Best Local LLMs for the AMD Ryzen AI Max+ 395

Written by Jakub Rusinowski · Last updated July 12, 2026

Best all-round pick: GPT-oss 120B

The AMD Ryzen AI Max+ 395 has 96 GB of VRAM, of which about 96 GB is available to a model. The largest model it can hold is Devstral-2 123B (123B, 75.1 GB at Q4_K_M).

Best models overall on the AMD Ryzen AI Max+ 395

Model	Score	Memory at Q4_K_M	Context	Licence
GPT-oss 120B	96.4	73.3 GB	125K	Apache-2.0
Nemotron 70B Instruct	96.2	43.4 GB	125K	Llama Community
Qwen 3.5 122B-A10B (MoE)	94.4	74.5 GB	125K	Apache 2.0
GLM-5.1 72B	92.8	44.3 GB	125K	MIT
Qwen 3.5 122B-A10B	92.8	74.5 GB	128K	Apache-2.0
Command R+ (104B)	92.6	63.6 GB	125K	CC-BY-NC

Best model by what you are doing

Workload	Recommended on this GPU
Coding	Devstral-2 123B (98.7) Qwen3-Coder 80B-A3B (MoE) (97.6) Qwen 3.5 122B-A10B (MoE) (96.8)
General assistant	GPT-oss 120B (96.4) Nemotron 70B Instruct (96.2) Qwen 3.5 122B-A10B (MoE) (94.4)
Reasoning	GLM-5.1 72B (99.3) Qwen 3.5 122B-A10B (MoE) (97.1) Gemma 4 27B ⭐ (96.4)
RAG	Llama 4 Scout 17B (94.4) Gemma 4 31B (93.5) Llama 4.5 Scout (93.1)
Agents	Ternary Bonsai 27B (89.6) Qwen 3.5 122B-A10B (MoE) (87.7) GLM-5.1 72B (87)
Vision	Qwen 3.5 72B (98.2) Llama 3.2 90B Vision Instruct (96.8) Qwen 3.7 35B-A3B (93.9)

How these numbers are calculated

Usable memory is 96 GB of the card's 96 GB.
Fit is measured at Q4_K_M — quantized weights plus KV cache plus 0.8 GB runtime overhead.
Within this card's budget, models are ranked on how well they use the memory available, not on being small — so the recommendation scales with the hardware.

FAQ

What is the best LLM for the AMD Ryzen AI Max+ 395?

GPT-oss 120B is the strongest all-round pick that fits its 96 GB.

What is the largest model the AMD Ryzen AI Max+ 395 can run?

Devstral-2 123B — 123B parameters, needing 75.1 GB at Q4_K_M.

How much of the AMD Ryzen AI Max+ 395's memory can a model actually use?

About 96 GB of its 96 GB, before the desktop and runtime overhead are accounted for.

Compatibility Checks for the AMD Ryzen AI Max+ 395

By Workload

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