Can I Run Qwen 2.5 72B Instruct on NVIDIA RTX 6000 Ada Generation?

Name: LLM Configurator — GPU VRAM Checker
Author: LLM Configurator

作者： Jakub Rusinowski · 最后更新： 2026年8月15日

Yes. Qwen 2.5 72B Instruct needs 43.5 GB at Q4_K_M and the NVIDIA RTX 6000 Ada Generation has 48 GB, leaving about 4.5 GB of headroom, at roughly 19 tok/s (estimated) with room for up to 8K of context.

The numbers

Model	Qwen 2.5 72B Instruct
Parameters	72B
Quantization	Q4_K_M
VRAM needed	43.5 GB
NVIDIA RTX 6000 Ada Generation VRAM	48 GB
Verdict	Runs
Max context	8K
Estimated speed	~19 tok/s

What to do next

Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.

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Running Qwen 2.5 72B Instruct on this card:

NVIDIA RTX 6000 Ada Generation 48GB

48 GB VRAM · 300 W board power

2026年价格波动较大——请以当前商品页价格为准。

在亚马逊查看价格

Buy vs. rent Qwen 2.5 72B Instruct

Buy the GPU

~$6,799

NVIDIA RTX 6000 Ada Generation · MSRP

Rent by the hour

from $0.77/hr

A100 (80 GB) class

At 2 hrs/day, buying (~$6,799) beats renting at $0.77/hr after about 12.3 years.

Affiliate links — we may earn a commission if you sign up, at no extra cost to you.

Vast.ai $0.77/hr · typical low · varies

Rent on Vast.ai →

RunPod $1.39/hr

Rent on RunPod →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other Qwen 2.5 Family sizes on the NVIDIA RTX 6000 Ada Generation

Qwen 2.5 Coder 32B — runs (19.3 GB)
Qwen 2.5 14B Instruct — runs (8.5 GB)
Qwen 2.5 7B Instruct — runs (4.6 GB)

Qwen 2.5 72B Instruct on nearby hardware

Apple M3 Pro (36 GB) — runs at a lower quant
Apple M3 Max (64 GB) — runs

All Qwen 2.5 Family sizes on the NVIDIA RTX 6000 Ada Generation | VRAM calculator for Qwen 2.5 72B Instruct | NVIDIA RTX 6000 Ada Generation GPU page | Check your hardware