Can I Run Qwen 2.5 72B Instruct on NVIDIA L40S?

Autor: Jakub Rusinowski · Ostatnia aktualizacja: 15 sierpnia 2026

Yes. Qwen 2.5 72B Instruct needs 43.5 GB at Q4_K_M and the NVIDIA L40S has 48 GB, leaving about 4.5 GB of headroom, at roughly 17 tok/s (estimated) with room for up to 8K of context.

The numbers

ModelQwen 2.5 72B Instruct
Parameters72B
QuantizationQ4_K_M
VRAM needed43.5 GB
NVIDIA L40S VRAM48 GB
VerdictRuns
Max context8K
Estimated speed~17 tok/s

What to do next

Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.

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Running Qwen 2.5 72B Instruct on this card:

NVIDIA L40S 48GB
48 GB VRAM · 350 W board power
Ceny w 2026 są niestabilne — sprawdź aktualną ofertę.
Sprawdź cenę na Amazon

Buy vs. rent Qwen 2.5 72B Instruct
Buy the GPU
~$7,499
NVIDIA L40S · MSRP
Rent by the hour
from $0.77/hr
A100 (80 GB) class

At 2 hrs/day, buying (~$7,499) beats renting at $0.77/hr after about 13.5 years.

Affiliate links — we may earn a commission if you sign up, at no extra cost to you.

Vast.ai $0.77/hr · typical low · varies
Rent on Vast.ai →
RunPod $1.39/hr
Rent on RunPod →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other Qwen 2.5 Family sizes on the NVIDIA L40S

Qwen 2.5 72B Instruct on nearby hardware

All Qwen 2.5 Family sizes on the NVIDIA L40S | VRAM calculator for Qwen 2.5 72B Instruct | NVIDIA L40S GPU page | Check your hardware