Can I Run Qwen 2.5 72B Instruct on NVIDIA GeForce RTX 4080?

Autor: Jakub Rusinowski · Ostatnia aktualizacja: 15 sierpnia 2026

No. Qwen 2.5 72B Instruct needs 43.5 GB at Q4_K_M and the NVIDIA GeForce RTX 4080 has only 16 GB. No quantization we publish closes a gap that size.

The numbers

ModelQwen 2.5 72B Instruct
Parameters72B
QuantizationQ4_K_M
VRAM needed43.5 GB
NVIDIA GeForce RTX 4080 VRAM16 GB
VerdictDoes not fit

What to do next

Either step down to a smaller size in this family, or move to a NVIDIA RTX 6000 Ada Generation (48 GB), the cheapest card we track with enough VRAM.

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Cheapest card we track with enough VRAM for Qwen 2.5 72B Instruct:

NVIDIA RTX 6000 Ada Generation 48GB
48 GB VRAM · 300 W board power
Ceny w 2026 są niestabilne — sprawdź aktualną ofertę.
Sprawdź cenę na Amazon

Won't fit — rent Qwen 2.5 72B Instruct instead

Qwen 2.5 72B Instruct needs ~43 GB but this GPU has 16 GB. Rent a A100 (80 GB)-class GPU by the hour instead of buying one:

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Vast.ai $0.77/hr · typical low · varies
Rent on Vast.ai →
RunPod $1.39/hr
Rent on RunPod →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other Qwen 2.5 Family sizes on the NVIDIA GeForce RTX 4080

Qwen 2.5 72B Instruct on nearby hardware

All Qwen 2.5 Family sizes on the NVIDIA GeForce RTX 4080 | VRAM calculator for Qwen 2.5 72B Instruct | NVIDIA GeForce RTX 4080 GPU page | Check your hardware