Can I Run Qwen 2.5 72B Instruct on AMD Ryzen AI Max+ 395?

Autor: Jakub Rusinowski · Ostatnia aktualizacja: 15 sierpnia 2026

Yes. Qwen 2.5 72B Instruct needs 43.5 GB at Q4_K_M and the AMD Ryzen AI Max+ 395 has 96 GB, leaving about 52.5 GB of headroom, at roughly 4 tok/s (estimated) with room for up to 128K of context.

The numbers

ModelQwen 2.5 72B Instruct
Parameters72B
QuantizationQ4_K_M
VRAM needed43.5 GB
AMD Ryzen AI Max+ 395 VRAM96 GB
VerdictRuns
Max context128K
Estimated speed~4 tok/s

What to do next

Nothing to change — run it at Q4_K_M. If you want more capability, check whether the next size up also fits.

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Running Qwen 2.5 72B Instruct on this card:

Ryzen AI Max+ 395 Laptop (Strix Halo, up to 128GB)
96 GB VRAM · 120 W board power
Ceny w 2026 są niestabilne — sprawdź aktualną ofertę.
Sprawdź cenę na Amazon

Buy vs. rent Qwen 2.5 72B Instruct
Buy the GPU
~$1,999
AMD Ryzen AI Max+ 395 · MSRP
Rent by the hour
from $0.77/hr
A100 (80 GB) class

At 2 hrs/day, buying (~$1,999) beats renting at $0.77/hr after about 3.6 years.

Affiliate links — we may earn a commission if you sign up, at no extra cost to you.

Vast.ai $0.77/hr · typical low · varies
Rent on Vast.ai →
RunPod $1.39/hr
Rent on RunPod →

Cloud rates verified 2026-07 — estimates, and marketplace prices vary. Buying price is GPU MSRP only, not a full PC.

Other Qwen 2.5 Family sizes on the AMD Ryzen AI Max+ 395

Qwen 2.5 72B Instruct on nearby hardware

All Qwen 2.5 Family sizes on the AMD Ryzen AI Max+ 395 | VRAM calculator for Qwen 2.5 72B Instruct | AMD Ryzen AI Max+ 395 GPU page | Check your hardware